6egu
From Proteopedia
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<StructureSection load='6egu' size='340' side='right' caption='[[6egu]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='6egu' size='340' side='right' caption='[[6egu]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6egu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6egu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rvfv Rvfv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EGU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EGU FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43Y:[(2R)-3-[OXIDANYL-[2-(TRIMETHYL-$L^{4}-AZANYL)ETHOXY]PHOSPHORYL]OXY-2-PROPANOYLOXY-PROPYL]+PROPANOATE'>43Y</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [http://pdbe.org/6egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [http://www.ebi.ac.uk/pdbsum/6egu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6egu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6egu OCA], [http://pdbe.org/6egu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6egu RCSB], [http://www.ebi.ac.uk/pdbsum/6egu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6egu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe disease in humans and livestock across Africa. We determined the x-ray structure of the RVFV class II fusion protein Gc in its postfusion form and in complex with a glycerophospholipid (GPL) bound in a conserved cavity next to the fusion loop. Site-directed mutagenesis and molecular dynamics simulations further revealed a built-in motif allowing en bloc insertion of the fusion loop into membranes, making few nonpolar side-chain interactions with the aliphatic moiety and multiple polar interactions with lipid head groups upon membrane restructuring. The GPL head-group recognition pocket is conserved in the fusion proteins of other arthropod-borne viruses, such as Zika and chikungunya viruses, which have recently caused major epidemics worldwide. | ||
| + | |||
| + | A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.,Guardado-Calvo P, Atkovska K, Jeffers SA, Grau N, Backovic M, Perez-Vargas J, de Boer SM, Tortorici MA, Pehau-Arnaudet G, Lepault J, England P, Rottier PJ, Bosch BJ, Hub JS, Rey FA Science. 2017 Nov 3;358(6363):663-667. doi: 10.1126/science.aal2712. PMID:29097548<ref>PMID:29097548</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6egu" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Rvfv]] | ||
[[Category: GUARDADO-CALVO, P]] | [[Category: GUARDADO-CALVO, P]] | ||
[[Category: REY, F A]] | [[Category: REY, F A]] | ||
[[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]] | [[Category: Viral fusion envelope glycoprotein bunyavirus phlebovirus]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 10:19, 15 November 2017
Structure of RVFV envelope protein Gc in postfusion conformation in complex with 1,2-dipropionyl-sn-glycero-3-phosphocholine
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