3fvc

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==Crystal structure of a trimeric variant of the Epstein-Barr virus glycoprotein B==
==Crystal structure of a trimeric variant of the Epstein-Barr virus glycoprotein B==
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<StructureSection load='3fvc' size='340' side='right' caption='[[3fvc]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='3fvc' size='340' side='right'caption='[[3fvc]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fvc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvb9 Ebvb9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FVC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fvc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebvb9 Ebvb9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BALF4, VGLB_EBV ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10377 EBVB9])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BALF4, VGLB_EBV ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10377 EBVB9])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvc OCA], [http://pdbe.org/3fvc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fvc RCSB], [http://www.ebi.ac.uk/pdbsum/3fvc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fvc OCA], [https://pdbe.org/3fvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fvc RCSB], [https://www.ebi.ac.uk/pdbsum/3fvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fvc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GB_EBVB9 GB_EBVB9]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gp350/220 to its receptor, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity).
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[[https://www.uniprot.org/uniprot/GB_EBVB9 GB_EBVB9]] Envelope glycoprotein that forms spikes at the surface of virion envelope. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding of gp350/220 to its receptor, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvc_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fvc_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Ebvb9]]
[[Category: Ebvb9]]
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[[Category: Large Structures]]
[[Category: Backovic, M]]
[[Category: Backovic, M]]
[[Category: Fusion loop]]
[[Category: Fusion loop]]

Revision as of 19:58, 20 October 2021

Crystal structure of a trimeric variant of the Epstein-Barr virus glycoprotein B

PDB ID 3fvc

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