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3h21
From Proteopedia
(Difference between revisions)
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==Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase== | ==Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase== | ||
| - | <StructureSection load='3h21' size='340' side='right' caption='[[3h21]], [[Resolution|resolution]] 2.32Å' scene=''> | + | <StructureSection load='3h21' size='340' side='right'caption='[[3h21]], [[Resolution|resolution]] 2.32Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3h21]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3h21]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_a2012 Bacillus anthracis a2012]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H21 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B52:(2R)-2-(7-AMINO-1-METHYL-4,5-DIOXO-1,4,5,6-TETRAHYDROPYRIMIDO[4,5-C]PYRIDAZIN-3-YL)PROPANOIC+ACID'>B52</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B52:(2R)-2-(7-AMINO-1-METHYL-4,5-DIOXO-1,4,5,6-TETRAHYDROPYRIMIDO[4,5-C]PYRIDAZIN-3-YL)PROPANOIC+ACID'>B52</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tww|1tww]], [[1twz|1twz]], [[1tx0|1tx0]], [[1tx2|1tx2]], [[1tws|1tws]], [[3h22|3h22]], [[3h23|3h23]], [[3h24|3h24]], [[3h26|3h26]], [[3h2a|3h2a]], [[3h2c|3h2c]], [[3h2e|3h2e]], [[3h2f|3h2f]], [[3h2m|3h2m]], [[3h2n|3h2n]], [[3h2o|3h2o]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1tww|1tww]], [[1twz|1twz]], [[1tx0|1tx0]], [[1tx2|1tx2]], [[1tws|1tws]], [[3h22|3h22]], [[3h23|3h23]], [[3h24|3h24]], [[3h26|3h26]], [[3h2a|3h2a]], [[3h2c|3h2c]], [[3h2e|3h2e]], [[3h2f|3h2f]], [[3h2m|3h2m]], [[3h2n|3h2n]], [[3h2o|3h2o]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folP, BAO_0074 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folP, BAO_0074 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=191218 Bacillus anthracis A2012])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydropteroate_synthase Dihydropteroate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.15 2.5.1.15] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h21 OCA], [https://pdbe.org/3h21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h21 RCSB], [https://www.ebi.ac.uk/pdbsum/3h21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h21 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/3h21_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/3h21_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3h21" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3h21" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dihydropteroate synthase 3D structures|Dihydropteroate synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bacillus anthracis a2012]] | [[Category: Bacillus anthracis a2012]] | ||
[[Category: Dihydropteroate synthase]] | [[Category: Dihydropteroate synthase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: White, S W]] | [[Category: White, S W]] | ||
[[Category: Yun, M K]] | [[Category: Yun, M K]] | ||
Revision as of 08:00, 16 March 2022
Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase
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