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1zp5

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[[Image:1zp5.gif|left|200px]]
[[Image:1zp5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zp5 |SIZE=350|CAPTION= <scene name='initialview01'>1zp5</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1zp5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2NI:N-{2-[(4&#39;-CYANO-1,1&#39;-BIPHENYL-4-YL)OXY]ETHYL}-N&#39;-HYDROXY-N-METHYLUREA'>2NI</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MMP8, CLG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1zp5| PDB=1zp5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zp5 OCA], [http://www.ebi.ac.uk/pdbsum/1zp5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zp5 RCSB]</span>
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}}
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'''Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor'''
'''Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor'''
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[[Category: Tortorella, P.]]
[[Category: Tortorella, P.]]
[[Category: Tschesche, H.]]
[[Category: Tschesche, H.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:54:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:39:48 2008''
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Revision as of 14:54, 3 May 2008

Image:1zp5.gif

Template:STRUCTURE 1zp5

Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor


Overview

The first crystallographic structure of an N-hydroxyurea inhibitor bound into the active site of a matrix metalloproteinase is reported. The ligand and three other analogues were prepared and studied as inhibitors of MMP-2, MMP-3, and MMP-8. The crystal structure of the complex with MMP-8 shows that the N-hydroxyurea, contrary to the analogous hydroxamate, binds the catalytic zinc ion in a monodentate rather than bidentate mode and with high out-of-plane distortion of the amide bonds.

About this Structure

1ZP5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8., Campestre C, Agamennone M, Tortorella P, Preziuso S, Biasone A, Gavuzzo E, Pochetti G, Mazza F, Hiller O, Tschesche H, Consalvi V, Gallina C, Bioorg Med Chem Lett. 2006 Jan 1;16(1):20-4. Epub 2005 Oct 18. PMID:16242329 Page seeded by OCA on Sat May 3 17:54:09 2008

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