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3i6z
From Proteopedia
(Difference between revisions)
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==3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine== | ==3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine== | ||
| - | <StructureSection load='3i6z' size='340' side='right' caption='[[3i6z]], [[Resolution|resolution]] 2.19Å' scene=''> | + | <StructureSection load='3i6z' size='340' side='right'caption='[[3i6z]], [[Resolution|resolution]] 2.19Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3i6z]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3i6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I6Z FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G6X:2-{6-[(4AS,6R,8AS)-6-HYDROXY-3-METHOXY-5,6,9,10-TETRAHYDRO-4AH-[1]BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-11(12H)-YL]HEXYL}-1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>G6X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G6X:2-{6-[(4AS,6R,8AS)-6-HYDROXY-3-METHOXY-5,6,9,10-TETRAHYDRO-4AH-[1]BENZOFURO[3A,3,2-EF][2]BENZAZEPIN-11(12H)-YL]HEXYL}-1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>G6X</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1w4l|1w4l]], [[1w6r|1w6r]], [[1qti|1qti]], [[1w76|1w76]], [[1dx6|1dx6]], [[3i6m|3i6m]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w4l|1w4l]], [[1w6r|1w6r]], [[1qti|1qti]], [[1w76|1w76]], [[1dx6|1dx6]], [[3i6m|3i6m]]</div></td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i6z OCA], [https://pdbe.org/3i6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i6z RCSB], [https://www.ebi.ac.uk/pdbsum/3i6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i6z ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/3i6z_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/3i6z_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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==See Also== | ==See Also== | ||
*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] | ||
| - | *[[3D structures of acetylcholinesterase|3D structures of acetylcholinesterase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
[[Category: Bartolucci, C]] | [[Category: Bartolucci, C]] | ||
Revision as of 10:59, 13 April 2022
3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine
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Categories: Acetylcholinesterase | Large Structures | Torpedo californica | Bartolucci, C | Lamba, D | Alternative splicing | Alzheimer's disease | Bis-functional galanthamine derivative | Cell junction | Cell membrane | Cholinesterase | Disulfide bond | Glycoprotein | Gpi-anchor | Hydrolase | Lipoprotein | Membrane | Neurotransmitter degradation | Serine esterase | Serine hydrolase | Synapse
