1zq1

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[[Image:1zq1.gif|left|200px]]
[[Image:1zq1.gif|left|200px]]
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{{Structure
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|PDB= 1zq1 |SIZE=350|CAPTION= <scene name='initialview01'>1zq1</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1zq1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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|ACTIVITY=
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|GENE= gatD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29292 Pyrococcus abyssi]), gatE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29292 Pyrococcus abyssi])
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|DOMAIN=
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{{STRUCTURE_1zq1| PDB=1zq1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zq1 OCA], [http://www.ebi.ac.uk/pdbsum/1zq1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zq1 RCSB]</span>
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'''Structure of GatDE tRNA-Dependent Amidotransferase from Pyrococcus abyssi'''
'''Structure of GatDE tRNA-Dependent Amidotransferase from Pyrococcus abyssi'''
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[[Category: Schmitt, E.]]
[[Category: Schmitt, E.]]
[[Category: 3d structure]]
[[Category: 3d structure]]
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[[Category: asparaginase 1 family]]
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[[Category: Asparaginase 1 family]]
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[[Category: gatd subfamily]]
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[[Category: Gatd subfamily]]
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[[Category: x-ray]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:55:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:40:06 2008''
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Revision as of 14:55, 3 May 2008

Image:1zq1.gif

Template:STRUCTURE 1zq1

Structure of GatDE tRNA-Dependent Amidotransferase from Pyrococcus abyssi


Overview

Besides direct charging of tRNAs by aminoacyl-tRNA synthetases, indirect routes also ensure attachment of some amino acids onto tRNA. Such routes may explain how new amino acids entered into protein synthesis. In archaea and in most bacteria, tRNA(Gln) is first misaminoacylated by glutamyl-tRNA synthetase. Glu-tRNA(Gln) is then matured into Gln-tRNA(Gln) by a tRNA-dependent amidotransferase. We report the structure of a tRNA-dependent amidotransferase-that of GatDE from Pyrococcus abyssi. The 3.0 A resolution crystal structure shows a tetramer with two GatD molecules as the core and two GatE molecules at the periphery. The fold of GatE cannot be related to that of any tRNA binding enzyme. The ammonium donor site on GatD and the tRNA site on GatE are markedly distant. Comparison of GatD and L-asparaginase structures shows how the motion of a beta hairpin region containing a crucial catalytic threonine may control the overall reaction cycle of GatDE.

About this Structure

1ZQ1 is a Protein complex structure of sequences from Pyrococcus abyssi. Full crystallographic information is available from OCA.

Reference

Structural basis for tRNA-dependent amidotransferase function., Schmitt E, Panvert M, Blanquet S, Mechulam Y, Structure. 2005 Oct;13(10):1421-33. PMID:16216574 Page seeded by OCA on Sat May 3 17:55:48 2008

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