1zro

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[[Image:1zro.gif|left|200px]]
[[Image:1zro.gif|left|200px]]
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{{Structure
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|PDB= 1zro |SIZE=350|CAPTION= <scene name='initialview01'>1zro</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_1zro", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1zro| PDB=1zro | SCENE= }}
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|RELATEDENTRY=[[1zrl|1ZRL]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zro OCA], [http://www.ebi.ac.uk/pdbsum/1zro PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zro RCSB]</span>
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'''Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose'''
'''Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose'''
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[[Category: Sim, B K.]]
[[Category: Sim, B K.]]
[[Category: Tolia, N H.]]
[[Category: Tolia, N H.]]
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[[Category: binding]]
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[[Category: Binding]]
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[[Category: dbl]]
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[[Category: Dbl]]
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[[Category: disease]]
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[[Category: Disease]]
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[[Category: eba-175]]
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[[Category: Eba-175]]
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[[Category: erythrocyte]]
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[[Category: Erythrocyte]]
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[[Category: glycan]]
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[[Category: Glycan]]
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[[Category: glycophorin]]
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[[Category: Glycophorin]]
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[[Category: host]]
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[[Category: Host]]
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[[Category: invasion]]
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[[Category: Invasion]]
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[[Category: malaria]]
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[[Category: Malaria]]
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[[Category: rii]]
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[[Category: Rii]]
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[[Category: sialic acid]]
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[[Category: Sialic acid]]
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[[Category: sialyllactose]]
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[[Category: Sialyllactose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:59:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:40:43 2008''
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Revision as of 14:59, 3 May 2008

Image:1zro.gif

Template:STRUCTURE 1zro

Crystal structure of EBA-175 Region II (RII) crystallized in the presence of (alpha)2,3-sialyllactose


Overview

Erythrocyte binding antigen 175 (EBA-175) is a P. falciparum protein that binds the major glycoprotein found on human erythrocytes, glycophorin A, during invasion. Here we present the crystal structure of the erythrocyte binding domain of EBA-175, RII, which has been established as a vaccine candidate. Binding sites for the heavily sialylated receptor glycophorin A are proposed based on a complex of RII with a glycan that contains the essential components required for binding. The dimeric organization of RII displays two prominent channels that contain four of the six observed glycan binding sites. Each monomer consists of two Duffy binding-like (DBL) domains (F1 and F2). F2 more prominently lines the channels and makes the majority of the glycan contacts, underscoring its role in cytoadherence and in antigenic variation in malaria. Our studies provide insight into the mechanism of erythrocyte invasion by the malaria parasite and aid in rational drug design and vaccines.

About this Structure

1ZRO is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

Reference

Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum., Tolia NH, Enemark EJ, Sim BK, Joshua-Tor L, Cell. 2005 Jul 29;122(2):183-93. PMID:16051144 Page seeded by OCA on Sat May 3 17:59:13 2008

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