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5cbh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbh OCA], [http://pdbe.org/5cbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbh RCSB], [http://www.ebi.ac.uk/pdbsum/5cbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbh ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbh OCA], [http://pdbe.org/5cbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cbh RCSB], [http://www.ebi.ac.uk/pdbsum/5cbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The selectivity filter is an essential functional element of K(+) channels that is highly conserved both in terms of its primary sequence and its three-dimensional structure. Here, we investigate the properties of an ion channel from the Gram-positive bacterium Tsukamurella paurometabola with a selectivity filter formed by an uncommon proline-rich sequence. Electrophysiological recordings show that it is a non-selective cation channel and that its activity depends on Ca(2+) concentration. In the crystal structure, the selectivity filter adopts a novel conformation with Ca(2+) ions bound within the filter near the pore helix where they are coordinated by backbone oxygen atoms, a recurrent motif found in multiple proteins. The binding of Ca(2+) ion in the selectivity filter controls the widening of the pore as shown in crystal structures and in molecular dynamics simulations. The structural, functional and computational data provide a characterization of this calcium-gated cationic channel. | ||
| + | |||
| + | Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola.,Dhakshnamoorthy B, Rohaim A, Rui H, Blachowicz L, Roux B Nat Commun. 2016 Sep 28;7:12753. doi: 10.1038/ncomms12753. PMID:27678077<ref>PMID:27678077</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5cbh" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Corynebacterium paurometabolum]] | [[Category: Corynebacterium paurometabolum]] | ||
| - | [[Category: | + | [[Category: Blachowicz, L]] |
| - | [[Category: | + | [[Category: Dhakshnamoorthy, B]] |
| + | [[Category: Rohaim, A]] | ||
| + | [[Category: Roux, B]] | ||
| + | [[Category: Rui, H]] | ||
[[Category: 2tm helix ion channel family]] | [[Category: 2tm helix ion channel family]] | ||
[[Category: Calcium activated non-selective ion channel]] | [[Category: Calcium activated non-selective ion channel]] | ||
Revision as of 06:02, 8 March 2018
Structural and Functional Characterization of a Calcium-activated Cation channel from Tsukamurella Paurometabola
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