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1zt4

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[[Image:1zt4.gif|left|200px]]
[[Image:1zt4.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zt4 |SIZE=350|CAPTION= <scene name='initialview01'>1zt4</scene>, resolution 3.000&Aring;
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The line below this paragraph, containing "STRUCTURE_1zt4", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=AGH:N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE'>AGH</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CD1D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1zt4| PDB=1zt4 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt4 OCA], [http://www.ebi.ac.uk/pdbsum/1zt4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zt4 RCSB]</span>
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}}
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'''The crystal structure of human CD1d with and without alpha-Galactosylceramide'''
'''The crystal structure of human CD1d with and without alpha-Galactosylceramide'''
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[[Category: Shepherd, D.]]
[[Category: Shepherd, D.]]
[[Category: Stronge, V S.]]
[[Category: Stronge, V S.]]
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[[Category: alpha-galactosylceramide]]
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[[Category: Alpha-galactosylceramide]]
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[[Category: alpha-galcer]]
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[[Category: Alpha-galcer]]
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[[Category: cd1]]
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[[Category: Cd1]]
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[[Category: empty binding groove]]
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[[Category: Empty binding groove]]
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[[Category: glycolipid]]
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[[Category: Glycolipid]]
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[[Category: human cd1d]]
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[[Category: Human cd1d]]
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[[Category: mhc class i]]
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[[Category: Mhc class i]]
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[[Category: spine]]
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[[Category: Spine]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural proteomics in europe]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 13 08:16:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:41:16 2008''
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Revision as of 05:16, 13 April 2008

Image:1zt4.gif

Template:STRUCTURE 1zt4

The crystal structure of human CD1d with and without alpha-Galactosylceramide


Contents

Overview

The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sphingosine chain bound in the C' pocket and the longer acyl chain anchored in the A' pocket. We also present the CD1d structure without lipid, which has a more open conformation of the binding groove, suggesting a dual conformation of CD1d in which the 'open' conformation is more able to load lipids. These structures provide clues as to how CD1 molecules load glycolipids as well as data to guide the design of new therapeutic agents.

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1ZT4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human CD1d with and without alpha-galactosylceramide., Koch M, Stronge VS, Shepherd D, Gadola SD, Mathew B, Ritter G, Fersht AR, Besra GS, Schmidt RR, Jones EY, Cerundolo V, Nat Immunol. 2005 Aug;6(8):819-26. Epub 2005 Jul 10. PMID:16007090 Page seeded by OCA on Sun Apr 13 08:16:48 2008

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OCA

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