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1zt2

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[[Image:1zt2.gif|left|200px]]
[[Image:1zt2.gif|left|200px]]
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{{Structure
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|PDB= 1zt2 |SIZE=350|CAPTION= <scene name='initialview01'>1zt2</scene>, resolution 3.33&Aring;
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The line below this paragraph, containing "STRUCTURE_1zt2", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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|GENE= priA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus]), priB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])
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|DOMAIN=
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{{STRUCTURE_1zt2| PDB=1zt2 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zt2 OCA], [http://www.ebi.ac.uk/pdbsum/1zt2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zt2 RCSB]</span>
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'''Heterodimeric structure of the core primase.'''
'''Heterodimeric structure of the core primase.'''
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[[Category: Pellegrini, L.]]
[[Category: Pellegrini, L.]]
[[Category: Roversi, P.]]
[[Category: Roversi, P.]]
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[[Category: heterodimeric complex]]
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[[Category: Heterodimeric complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:02:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:41:16 2008''
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Revision as of 15:02, 3 May 2008

Image:1zt2.gif

Template:STRUCTURE 1zt2

Heterodimeric structure of the core primase.


Overview

Primases are DNA-dependent RNA polymerases that synthesize the oligoribonucleotide primers essential to DNA replication. In archaeal and eukaryotic organisms, the core primase is a heterodimeric enzyme composed of a small and a large subunit. Here we report a crystallographic and biochemical analysis of the core primase from the archaeon Sulfolobus solfataricus. The structure provides the first three-dimensional description of the large subunit and its interaction with the small subunit. The evolutionary conservation of amino acids at the protein-protein interface implies that the observed mode of subunit association is conserved among archaeal and eukaryotic primases. The orientation of the large subunit in the core primase probably excludes its direct involvement in catalysis. Modeling of a DNA-RNA helix together with structure-based site-directed mutagenesis provides insight into the mechanism of template DNA binding and RNA primer synthesis.

About this Structure

1ZT2 is a Protein complex structure of sequences from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Structure of the heterodimeric core primase., Lao-Sirieix SH, Nookala RK, Roversi P, Bell SD, Pellegrini L, Nat Struct Mol Biol. 2005 Dec;12(12):1137-44. Epub 2005 Nov 6. PMID:16273105 Page seeded by OCA on Sat May 3 18:02:12 2008

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