1zu4
From Proteopedia
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'''Crystal structure of FtsY from Mycoplasma mycoides- space group P21212''' | '''Crystal structure of FtsY from Mycoplasma mycoides- space group P21212''' | ||
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[[Category: Samuelsson, T.]] | [[Category: Samuelsson, T.]] | ||
[[Category: Sauer-Eriksson, A E.]] | [[Category: Sauer-Eriksson, A E.]] | ||
| - | [[Category: | + | [[Category: Ftsy]] |
| - | [[Category: | + | [[Category: Gtpase]] |
| - | [[Category: | + | [[Category: Receptor]] |
| - | [[Category: | + | [[Category: Signal recognition particle]] |
| - | [[Category: | + | [[Category: Srp]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:04:46 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:04, 3 May 2008
Crystal structure of FtsY from Mycoplasma mycoides- space group P21212
Overview
The prokaryotic signal recognition particle Ffh and its receptor FtsY allow targeting of proteins into or across the plasma membrane. The targeting process is GTP dependent and the two proteins constitute a distinct GTPase family. The receptor FtsY is composed of A and NG domains where the NG's GTPase domain plays a critical role in the targeting process. In this study, we describe two X-ray structures determined independently of each other of the NG domain of FtsY from Mycoplasma mycoides (MmFtsY). The two structures are markedly different in three of the nucleotide-binding segments, GI (P-loop), GII, and GIII, making only one of the structures compatible with nucleotide binding. Interestingly, the two distinct conformations of the nucleotide-binding segments of MmFtsY are similar to the apo- and ADP-loaded forms of certain ATPases. The structure of the extended interface between the A and NG domains of MmFtsY provides new insights into the role of the A domain for phospholipid interaction.
About this Structure
1ZU4 is a Single protein structure of sequence from Mycoplasma mycoides. Full crystallographic information is available from OCA.
Reference
Conformational variability of the GTPase domain of the signal recognition particle receptor FtsY., Gariani T, Samuelsson T, Sauer-Eriksson AE, J Struct Biol. 2006 Jan;153(1):85-96. Epub 2005 Nov 30. PMID:16343944 Page seeded by OCA on Sat May 3 18:04:46 2008
