1zww

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[[Image:1zww.gif|left|200px]]
[[Image:1zww.gif|left|200px]]
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{{Structure
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|PDB= 1zww |SIZE=350|CAPTION= <scene name='initialview01'>1zww</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1zww", creates the "Structure Box" on the page.
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|SITE=
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|GENE= Sh3gl2, Sh3d2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_1zww| PDB=1zww | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zww OCA], [http://www.ebi.ac.uk/pdbsum/1zww PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zww RCSB]</span>
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'''Crystal structure of endophilin-A1 BAR domain'''
'''Crystal structure of endophilin-A1 BAR domain'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Weissenhorn, W.]]
[[Category: Weissenhorn, W.]]
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[[Category: coiled coil]]
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[[Category: Coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:10:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:42:41 2008''
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Revision as of 15:10, 3 May 2008

Image:1zww.gif

Template:STRUCTURE 1zww

Crystal structure of endophilin-A1 BAR domain


Overview

Endophilin has been implicated in the retrieval of membrane via endocytosis of clathrin-coated vesicles, which is crucial for the maintenance of neurotransmitter exocytosis during stimulation; both exocytosis and endocytosis are regulated by intracellular calcium levels. Here, we present the 2.3 A crystal structure of the endophilin-A1 BAR domain, which has been suggested to function in inducing and sensing membrane curvature at the site of endocytosis. Endo-BAR folds into a crescent-shaped dimer composed of two elongated, three-helix bundles. Two additional domains of 30 residues each, inserted into helix 1 at the center of the concave side of the dimer, may interfere with the proposed mode of BAR domain membrane interaction. In addition, the dimer binds 11 divalent cadmium ions in the crystal mostly with typical Ca2+ co-ordination spheres. The endophilin-1A BAR domain thus constitutes a new variant of a BAR domain, and it may link endophilin-1A BAR function to calcium regulation of endocytosis.

About this Structure

1ZWW is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the endophilin-A1 BAR domain., Weissenhorn W, J Mol Biol. 2005 Aug 19;351(3):653-61. PMID:16023669 Page seeded by OCA on Sat May 3 18:10:40 2008

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