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4tmf

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==Crystal structure of human CD38 in complex with hydrolysed compound JMS713==
==Crystal structure of human CD38 in complex with hydrolysed compound JMS713==
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<StructureSection load='4tmf' size='340' side='right' caption='[[4tmf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='4tmf' size='340' side='right'caption='[[4tmf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tmf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TMF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tmf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TMF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JS2:5-O-[(R)-{[(S)-[4-(8-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)BUTOXY](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]-ALPHA-D-RIBOFURANOSE'>JS2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JS2:5-O-[(R)-{[(S)-[4-(8-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)BUTOXY](HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]-ALPHA-D-RIBOFURANOSE'>JS2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmf OCA], [https://pdbe.org/4tmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tmf RCSB], [https://www.ebi.ac.uk/pdbsum/4tmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tmf ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmf OCA], [http://pdbe.org/4tmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tmf RCSB], [http://www.ebi.ac.uk/pdbsum/4tmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tmf ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Hao, Q]]
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[[Category: Large Structures]]
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[[Category: Potter, B]]
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[[Category: Hao Q]]
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[[Category: Swarbrick, J]]
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[[Category: Potter B]]
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[[Category: Zhang, H]]
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[[Category: Swarbrick J]]
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[[Category: Adp-ribosyl cyclase]]
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[[Category: Zhang H]]
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[[Category: Calcium signaling]]
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[[Category: Cd38]]
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[[Category: Cyclic adp-ribose]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitory compound]]
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[[Category: Jms713]]
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[[Category: X-crystallography]]
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Revision as of 10:46, 15 March 2023

Crystal structure of human CD38 in complex with hydrolysed compound JMS713

PDB ID 4tmf

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