4tzc

<StructureSection load='4tzc' size='340' side='right' caption='[[4tzc]], [[Resolution|resolution]] 1.88&Aring;' scene=''>

<table><tr><td colspan='2'>[[4tzc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TZC FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EF2:S-THALIDOMIDE'>EF2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Crbn ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tzc OCA], [http://pdbe.org/4tzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tzc RCSB], [http://www.ebi.ac.uk/pdbsum/4tzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tzc ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CRBN_MOUSE CRBN_MOUSE]] Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).

[[Category: Lk3 transgenic mice]]

[[Category: Chamberlain, P P]]

[[Category: Delker, S]]

[[Category: Leon, B]]

[[Category: Pagarigan, B]]

[[Category: Dcaf]]

[[Category: Ubiquitin ligase]]