1zxn

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[[Image:1zxn.gif|left|200px]]
[[Image:1zxn.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1zxn |SIZE=350|CAPTION= <scene name='initialview01'>1zxn</scene>, resolution 2.51&Aring;
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The line below this paragraph, containing "STRUCTURE_1zxn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TOP2A, TOP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1zxn| PDB=1zxn | SCENE= }}
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|RELATEDENTRY=[[1zxm|1ZXM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zxn OCA], [http://www.ebi.ac.uk/pdbsum/1zxn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1zxn RCSB]</span>
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}}
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'''Human DNA topoisomerase IIa ATPase/ADP'''
'''Human DNA topoisomerase IIa ATPase/ADP'''
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==Reference==
==Reference==
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase., Wei H, Ruthenburg AJ, Bechis SK, Verdine GL, J Biol Chem. 2005 Nov 4;280(44):37041-7. Epub 2005 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16100112 16100112]
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase., Wei H, Ruthenburg AJ, Bechis SK, Verdine GL, J Biol Chem. 2005 Nov 4;280(44):37041-7. Epub 2005 Aug 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16100112 16100112]
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[[Category: DNA topoisomerase (ATP-hydrolyzing)]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
[[Category: Wei, H.]]
[[Category: Wei, H.]]
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[[Category: ghkl nucleotide-binding fold]]
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[[Category: Ghkl nucleotide-binding fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:12:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:43:02 2008''
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Revision as of 15:12, 3 May 2008

Image:1zxn.gif

Template:STRUCTURE 1zxn

Human DNA topoisomerase IIa ATPase/ADP


Overview

Type IIA DNA topoisomerases play multiple essential roles in the management of higher-order DNA structure, including modulation of topological state, chromosome segregation, and chromatin condensation. These diverse physiologic functions are all accomplished through a common molecular mechanism, wherein the protein catalyzes transient cleavage of a DNA duplex (the G-segment) to yield a double-stranded gap through which another duplex (the T-segment) is passed. The overall process is orchestrated by the opening and closing of molecular "gates" in the topoisomerase structure, which is regulated by ATP binding, hydrolysis, and release of ADP and inorganic phosphate. Here we present two crystal structures of the ATPase domain of human DNA topoisomerase IIalpha in different nucleotide-bound states. Comparison of these structures revealed rigid-body movement of the structural modules within the ATPase domain, suggestive of the motions of a molecular gate.

About this Structure

1ZXN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase., Wei H, Ruthenburg AJ, Bechis SK, Verdine GL, J Biol Chem. 2005 Nov 4;280(44):37041-7. Epub 2005 Aug 12. PMID:16100112 Page seeded by OCA on Sat May 3 18:12:29 2008

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