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283d
From Proteopedia
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[[Image:283d.jpg|left|200px]] | [[Image:283d.jpg|left|200px]] | ||
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| - | + | {{STRUCTURE_283d| PDB=283d | SCENE= }} | |
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'''A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING''' | '''A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=283D OCA]. | |
==Reference== | ==Reference== | ||
A curved RNA helix incorporating an internal loop with G.A and A.A non-Watson-Crick base pairing., Baeyens KJ, De Bondt HL, Pardi A, Holbrook SR, Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12851-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8917508 8917508] | A curved RNA helix incorporating an internal loop with G.A and A.A non-Watson-Crick base pairing., Baeyens KJ, De Bondt HL, Pardi A, Holbrook SR, Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12851-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8917508 8917508] | ||
| - | [[Category: ]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Baeyens, K J.]] | [[Category: Baeyens, K J.]] | ||
[[Category: Bondt, H L.De.]] | [[Category: Bondt, H L.De.]] | ||
[[Category: Holbrook, S R.]] | [[Category: Holbrook, S R.]] | ||
[[Category: Pardi, A.]] | [[Category: Pardi, A.]] | ||
| - | [[Category: | + | [[Category: Curved]] |
| - | [[Category: | + | [[Category: Double helix]] |
| - | [[Category: | + | [[Category: Internal loop]] |
| - | [[Category: | + | [[Category: Mismatched]] |
| - | [[Category: | + | [[Category: Unusual rna]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:25:19 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 15:25, 3 May 2008
A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING
Overview
The crystal structure of the RNA dodecamer 5'-GGCC(GAAA)GGCC-3' has been determined from x-ray diffraction data to 2.3-A resolution. In the crystal, these oligomers form double helices around twofold symmetry axes. Four consecutive non-Watson-Crick base pairs make up an internal loop in the middle of the duplex, including sheared G.A pairs and novel asymmetric A.A pairs. This internal loop sequence produces a significant curvature and narrowing of the double helix. The helix is curved by 34 degrees from end to end and the diameter is narrowed by 24% in the internal loop. A Mn2+ ion is bound directly to the N7 of the first guanine in the Watson-Crick region following the internal loop and the phosphate of the preceding residue. This Mn2+ location corresponds to a metal binding site observed in the hammerhead catalytic RNA.
About this Structure
Full crystallographic information is available from OCA.
Reference
A curved RNA helix incorporating an internal loop with G.A and A.A non-Watson-Crick base pairing., Baeyens KJ, De Bondt HL, Pardi A, Holbrook SR, Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12851-5. PMID:8917508 Page seeded by OCA on Sat May 3 18:25:19 2008
