5vns
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==M.tb Antigen 85C Acyl-Enzyme Intermediate with Tetrahydrolipstatin== | |
| - | + | <StructureSection load='5vns' size='340' side='right' caption='[[5vns]], [[Resolution|resolution]] 1.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5vns]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VNS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VNS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DH9:(2S,3S,5S)-5-[(N-FORMYL-L-LEUCYL)OXY]-2-HEXYL-3-HYDROXYHEXADECANOIC+ACID'>DH9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vns FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vns OCA], [http://pdbe.org/5vns PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vns RCSB], [http://www.ebi.ac.uk/pdbsum/5vns PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vns ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A85C_MYCTO A85C_MYCTO]] The antigen 85 proteins (FbpA, FbpB, FbpC) are responsible for the high affinity of mycobacteria to fibronectin, a large adhesive glycoprotein, which facilitates the attachment of M.tuberculosis to murine alveolar macrophages (AMs). They also help to maintain the integrity of the cell wall by catalyzing the transfer of mycolic acids to cell wall arabinogalactan and through the synthesis of alpha,alpha-trehalose dimycolate (TDM, cord factor). They catalyze the transfer of a mycoloyl residue from one molecule of alpha,alpha-trehalose monomycolate (TMM) to another TMM, leading to the formation of TDM (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Goins, C M]] | ||
| + | [[Category: Ronning, D R]] | ||
| + | [[Category: Enzyme-acyl intermediate]] | ||
| + | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 18:24, 24 January 2018
M.tb Antigen 85C Acyl-Enzyme Intermediate with Tetrahydrolipstatin
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