6eq4

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m (Protected "6eq4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6eq4 is ON HOLD until Paper Publication
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==MTH1 in complex with fragment 8==
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<StructureSection load='6eq4' size='340' side='right' caption='[[6eq4]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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Authors: Wiedmer, L., Sledz, P., Caflisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6eq4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EQ4 FirstGlance]. <br>
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Description: MTH1 in complex with fragment 8
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BSW:4-(3-fluoranylpyridin-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine'>BSW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eq4 OCA], [http://pdbe.org/6eq4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eq4 RCSB], [http://www.ebi.ac.uk/pdbsum/6eq4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eq4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
[[Category: Sledz, P]]
[[Category: Sledz, P]]
[[Category: Wiedmer, L]]
[[Category: Wiedmer, L]]
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[[Category: Complex]]
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[[Category: Dna repair]]
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[[Category: Fragment]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]

Revision as of 06:53, 31 October 2018

MTH1 in complex with fragment 8

6eq4, resolution 1.40Å

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