2a2f

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[[Image:2a2f.gif|left|200px]]
[[Image:2a2f.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2a2f", creates the "Structure Box" on the page.
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|GENE= sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
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{{STRUCTURE_2a2f| PDB=2a2f | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB]</span>
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'''Crystal Structure of Sec15 C-terminal domain'''
'''Crystal Structure of Sec15 C-terminal domain'''
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[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
[[Category: Wu, S.]]
[[Category: Wu, S.]]
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[[Category: all helical structure]]
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[[Category: All helical structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:31:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:53 2008''
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Revision as of 15:31, 3 May 2008

Image:2a2f.gif

Template:STRUCTURE 2a2f

Crystal Structure of Sec15 C-terminal domain


Overview

Sec15, a component of the exocyst, recognizes vesicle-associated Rab GTPases, helps target transport vesicles to the budding sites in yeast and is thought to recruit other exocyst proteins. Here we report the characterization of a 35-kDa fragment that comprises most of the C-terminal half of Drosophila melanogaster Sec15. This C-terminal domain was found to bind a subset of Rab GTPases, especially Rab11, in a GTP-dependent manner. We also provide evidence that in fly photoreceptors Sec15 colocalizes with Rab11 and that loss of Sec15 affects rhabdomere morphology. Determination of the 2.5-A crystal structure of the C-terminal domain revealed a novel fold consisting of ten alpha-helices equally distributed between two subdomains (N and C subdomains). We show that the C subdomain, mainly via a single helix, is sufficient for Rab binding.

About this Structure

2A2F is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo., Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA, Nat Struct Mol Biol. 2005 Oct;12(10):879-85. Epub 2005 Sep 11. PMID:16155582 Page seeded by OCA on Sat May 3 18:31:03 2008

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