2a2e

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[[Image:2a2e.gif|left|200px]]
[[Image:2a2e.gif|left|200px]]
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{{Structure
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|PDB= 2a2e |SIZE=350|CAPTION= <scene name='initialview01'>2a2e</scene>, resolution 3.85&Aring;
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The line below this paragraph, containing "STRUCTURE_2a2e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|ACTIVITY=
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|DOMAIN=
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{{STRUCTURE_2a2e| PDB=2a2e | SCENE= }}
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|RELATEDENTRY=[[1u9s|1U9S]], [[1nbs|1NBS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2e OCA], [http://www.ebi.ac.uk/pdbsum/2a2e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a2e RCSB]</span>
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'''Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type.'''
'''Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type.'''
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==About this Structure==
==About this Structure==
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2A2E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2E OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2E OCA].
==Reference==
==Reference==
Crystal structure of the RNA component of bacterial ribonuclease P., Torres-Larios A, Swinger KK, Krasilnikov AS, Pan T, Mondragon A, Nature. 2005 Sep 22;437(7058):584-7. Epub 2005 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16113684 16113684]
Crystal structure of the RNA component of bacterial ribonuclease P., Torres-Larios A, Swinger KK, Krasilnikov AS, Pan T, Mondragon A, Nature. 2005 Sep 22;437(7058):584-7. Epub 2005 Aug 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16113684 16113684]
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[[Category: Protein complex]]
 
[[Category: Krasilnikov, A S.]]
[[Category: Krasilnikov, A S.]]
[[Category: Mondragon, A.]]
[[Category: Mondragon, A.]]
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[[Category: Swinger, K K.]]
[[Category: Swinger, K K.]]
[[Category: Torres-Larios, A.]]
[[Category: Torres-Larios, A.]]
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[[Category: coaxial helice]]
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[[Category: Coaxial helice]]
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[[Category: p rna]]
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[[Category: P rna]]
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[[Category: pre-trna]]
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[[Category: Pre-trna]]
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[[Category: ribonuclease p rna]]
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[[Category: Ribonuclease p rna]]
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[[Category: ribose zipper]]
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[[Category: Ribose zipper]]
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[[Category: ribozyme]]
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[[Category: Ribozyme]]
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[[Category: rnase p]]
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[[Category: Rnase p]]
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[[Category: t-loop]]
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[[Category: T-loop]]
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[[Category: tetraloop-receptor]]
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[[Category: Tetraloop-receptor]]
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[[Category: thermotoga maritima]]
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[[Category: Thermotoga maritima]]
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[[Category: trna]]
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[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:30:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:46:55 2008''
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Revision as of 15:31, 3 May 2008

Image:2a2e.gif

Template:STRUCTURE 2a2e

Crystal structure of the RNA subunit of Ribonuclease P. Bacterial A-type.


Overview

Transfer RNA (tRNA) is produced as a precursor molecule that needs to be processed at its 3' and 5' ends. Ribonuclease P is the sole endonuclease responsible for processing the 5' end of tRNA by cleaving the precursor and leading to tRNA maturation. It was one of the first catalytic RNA molecules identified and consists of a single RNA component in all organisms and only one protein component in bacteria. It is a true multi-turnover ribozyme and one of only two ribozymes (the other being the ribosome) that are conserved in all kingdoms of life. Here we show the crystal structure at 3.85 A resolution of the RNA component of Thermotoga maritima ribonuclease P. The entire RNA catalytic component is revealed, as well as the arrangement of the two structural domains. The structure shows the general architecture of the RNA molecule, the inter- and intra-domain interactions, the location of the universally conserved regions, the regions involved in pre-tRNA recognition and the location of the active site. A model with bound tRNA is in agreement with all existing data and suggests the general basis for RNA-RNA recognition by this ribozyme.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of the RNA component of bacterial ribonuclease P., Torres-Larios A, Swinger KK, Krasilnikov AS, Pan T, Mondragon A, Nature. 2005 Sep 22;437(7058):584-7. Epub 2005 Aug 21. PMID:16113684 Page seeded by OCA on Sat May 3 18:30:59 2008

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