2a4e

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[[Image:2a4e.gif|left|200px]]
[[Image:2a4e.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a4e |SIZE=350|CAPTION= <scene name='initialview01'>2a4e</scene>, resolution 3.200&Aring;
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The line below this paragraph, containing "STRUCTURE_2a4e", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2a4e| PDB=2a4e | SCENE= }}
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|RELATEDENTRY=[[1zvn|1ZVN]], [[1zxk|1ZXK]], [[2a4c|2A4C]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB]</span>
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}}
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'''Crystal structure of mouse cadherin-11 EC1-2'''
'''Crystal structure of mouse cadherin-11 EC1-2'''
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[[Category: Rajebhosale, M.]]
[[Category: Rajebhosale, M.]]
[[Category: Shapiro, L.]]
[[Category: Shapiro, L.]]
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[[Category: cadherin]]
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[[Category: Cadherin]]
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[[Category: calcium binding]]
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[[Category: Calcium binding]]
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[[Category: dimer]]
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[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:35:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:47:42 2008''
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Revision as of 15:35, 3 May 2008

Image:2a4e.gif

Template:STRUCTURE 2a4e

Crystal structure of mouse cadherin-11 EC1-2


Overview

Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

About this Structure

2A4E is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015 Page seeded by OCA on Sat May 3 18:35:10 2008

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