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3mdz

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Current revision (16:32, 1 November 2023) (edit) (undo)
 
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==Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7==
==Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7==
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<StructureSection load='3mdz' size='340' side='right' caption='[[3mdz]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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<StructureSection load='3mdz' size='340' side='right'caption='[[3mdz]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mdz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MDZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mdz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MDZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.32&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3caj|3caj]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EZL:6-ETHOXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE'>EZL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CA7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdz OCA], [https://pdbe.org/3mdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mdz RCSB], [https://www.ebi.ac.uk/pdbsum/3mdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdz ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mdz OCA], [http://pdbe.org/3mdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mdz RCSB], [http://www.ebi.ac.uk/pdbsum/3mdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mdz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CAH7_HUMAN CAH7_HUMAN]] Reversible hydration of carbon dioxide.
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[https://www.uniprot.org/uniprot/CAH7_HUMAN CAH7_HUMAN] Reversible hydration of carbon dioxide.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdz_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/md/3mdz_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mdz ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mdz ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carbonate dehydratase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bray, J]]
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[[Category: Bray J]]
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[[Category: Carpenter, E P]]
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[[Category: Carpenter EP]]
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[[Category: Chaikuad, A]]
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[[Category: Chaikuad A]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Kim J]]
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[[Category: Kim, J]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Muniz J]]
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[[Category: Muniz, J]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Pilka E]]
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[[Category: Pilka, E]]
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[[Category: Shafqat N]]
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[[Category: Structural genomic]]
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[[Category: Ugochukwu E]]
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[[Category: Shafqat, N]]
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[[Category: Weigelt J]]
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[[Category: Ugochukwu, E]]
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[[Category: Yue WW]]
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[[Category: Weigelt, J]]
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[[Category: Von Delft F]]
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[[Category: Yue, W W]]
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[[Category: Ca7]]
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[[Category: Carbonic anhydrase vii]]
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[[Category: Cytoplasm]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Sgc]]
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[[Category: Zinc]]
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Current revision

Crystal Structure of Human Carbonic Anhydrase VII [isoform 1], CA7

PDB ID 3mdz

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