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3qa2

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==X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2==
==X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2==
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<StructureSection load='3qa2' size='340' side='right' caption='[[3qa2]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
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<StructureSection load='3qa2' size='340' side='right'caption='[[3qa2]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3qa2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QA2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3qa2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QA2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XNA:N~8~-(CYCLOPROPYLMETHYL)-N~4~-(2-METHYLPHENYL)-2-(PIPERAZIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-4,8-DIAMINE'>XNA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XNA:N~8~-(CYCLOPROPYLMETHYL)-N~4~-(2-METHYLPHENYL)-2-(PIPERAZIN-1-YL)PYRIMIDO[5,4-D]PYRIMIDINE-4,8-DIAMINE'>XNA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q92|3q92]], [[3nbv|3nbv]], [[3nbw|3nbw]], [[3nc2|3nc2]], [[3nc9|3nc9]], [[3nca|3nca]], [[3qai|3qai]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3q92|3q92]], [[3nbv|3nbv]], [[3nbw|3nbw]], [[3nc2|3nc2]], [[3nc9|3nc9]], [[3nca|3nca]], [[3qai|3qai]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KHK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ketohexokinase Ketohexokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.3 2.7.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ketohexokinase Ketohexokinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.3 2.7.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qa2 OCA], [http://pdbe.org/3qa2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qa2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qa2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qa2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qa2 OCA], [https://pdbe.org/3qa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qa2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qa2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN]] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[http://omim.org/entry/229800 229800]]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref>
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[[https://www.uniprot.org/uniprot/KHK_HUMAN KHK_HUMAN]] Defects in KHK are the cause of fructosuria (FRUCT) [MIM:[https://omim.org/entry/229800 229800]]. Benign defect of intermediary metabolism.<ref>PMID:19237742</ref> <ref>PMID:7833921</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3qa2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3qa2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ketohexokinase|Ketohexokinase]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Human]]
[[Category: Human]]
[[Category: Ketohexokinase]]
[[Category: Ketohexokinase]]
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[[Category: Large Structures]]
[[Category: Abad, M C]]
[[Category: Abad, M C]]
[[Category: Atp binding]]
[[Category: Atp binding]]
[[Category: Transferase-transferase inhibitor complex]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 05:59, 8 June 2022

X-ray Structure of ketohexokinase in complex with a pyrimidopyrimidine analog 2

PDB ID 3qa2

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