3raj

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==Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7==
==Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7==
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<StructureSection load='3raj' size='340' side='right' caption='[[3raj]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
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<StructureSection load='3raj' size='340' side='right'caption='[[3raj]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3raj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RAJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3raj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAJ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD38 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3raj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raj OCA], [http://pdbe.org/3raj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3raj RCSB], [http://www.ebi.ac.uk/pdbsum/3raj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3raj ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3raj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raj OCA], [https://pdbe.org/3raj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3raj RCSB], [https://www.ebi.ac.uk/pdbsum/3raj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3raj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
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[[https://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
==See Also==
==See Also==
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*[[3D structures of antibody|3D structures of antibody]]
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Hao, Q]]
[[Category: Hao, Q]]

Revision as of 05:55, 15 June 2022

Crystal structure of human CD38 in complex with the Fab fragment of antibody HB7

PDB ID 3raj

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