3snp

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==Crystal structure analysis of iron regulatory protein 1 in complex with ferritin H IRE RNA==
==Crystal structure analysis of iron regulatory protein 1 in complex with ferritin H IRE RNA==
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<StructureSection load='3snp' size='340' side='right' caption='[[3snp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='3snp' size='340' side='right'caption='[[3snp]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3snp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ipy 2ipy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SNP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3snp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2ipy 2ipy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SNP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ipy|2ipy]], [[3sn2|3sn2]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ipy|2ipy]], [[3sn2|3sn2]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACO1, FRP, IREB1, IREBP, IRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACO1, FRP, IREB1, IREBP, IRP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3snp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3snp OCA], [http://pdbe.org/3snp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3snp RCSB], [http://www.ebi.ac.uk/pdbsum/3snp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3snp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3snp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3snp OCA], [https://pdbe.org/3snp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3snp RCSB], [https://www.ebi.ac.uk/pdbsum/3snp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3snp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACOC_RABIT ACOC_RABIT]] Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
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[[https://www.uniprot.org/uniprot/ACOC_RABIT ACOC_RABIT]] Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding (By similarity). Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3snp" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3snp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aconitase 3D structures|Aconitase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Aconitate hydratase]]
[[Category: Aconitate hydratase]]
[[Category: European rabbit]]
[[Category: European rabbit]]
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[[Category: Large Structures]]
[[Category: Selezneva, A I]]
[[Category: Selezneva, A I]]
[[Category: Volz, K]]
[[Category: Volz, K]]

Revision as of 08:03, 29 June 2022

Crystal structure analysis of iron regulatory protein 1 in complex with ferritin H IRE RNA

PDB ID 3snp

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