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3t3q
From Proteopedia
(Difference between revisions)
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==Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Pilocarpine== | ==Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Pilocarpine== | ||
| - | <StructureSection load='3t3q' size='340' side='right' caption='[[3t3q]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='3t3q' size='340' side='right'caption='[[3t3q]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3t3q]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3t3q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T3Q FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9PL:(3S,4R)-3-ETHYL-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]DIHYDROFURAN-2(3H)-ONE'>9PL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9PL:(3S,4R)-3-ETHYL-4-[(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]DIHYDROFURAN-2(3H)-ONE'>9PL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ebs|3ebs]], [[2fdy|2fdy]], [[1z11|1z11]], [[1z10|1z10]], [[2fdu|2fdu]], [[2fdv|2fdv]], [[2pg7|2pg7]], [[2pg6|2pg6]], [[2pg5|2pg5]], [[2fdw|2fdw]], [[3t3r|3t3r]], [[3t3s|3t3s]], [[3t3z|3t3z]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ebs|3ebs]], [[2fdy|2fdy]], [[1z11|1z11]], [[1z10|1z10]], [[2fdu|2fdu]], [[2fdv|2fdv]], [[2pg7|2pg7]], [[2pg6|2pg6]], [[2pg5|2pg5]], [[2fdw|2fdw]], [[3t3r|3t3r]], [[3t3s|3t3s]], [[3t3z|3t3z]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2A3, CYP2A6, CYP2A6 I208S/I300F/G301A/S369G ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2A3, CYP2A6, CYP2A6 I208S/I300F/G301A/S369G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t3q OCA], [https://pdbe.org/3t3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t3q RCSB], [https://www.ebi.ac.uk/pdbsum/3t3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t3q ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CP2A6_HUMAN CP2A6_HUMAN]] Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity.<ref>PMID:1889415</ref> <ref>PMID:1944238</ref> <ref>PMID:11695850</ref> <ref>PMID:16086027</ref> <ref>PMID:17125252</ref> <ref>PMID:18779312</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3t3q" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3t3q" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Unspecific monooxygenase]] | [[Category: Unspecific monooxygenase]] | ||
[[Category: DeVore, N M]] | [[Category: DeVore, N M]] | ||
Revision as of 16:41, 6 July 2022
Human Cytochrome P450 2A6 I208S/I300F/G301A/S369G in complex with Pilocarpine
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