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3u15

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==Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443==
==Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443==
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<StructureSection load='3u15' size='340' side='right' caption='[[3u15]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3u15' size='340' side='right'caption='[[3u15]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u15]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U15 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U15 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u15]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U15 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=03M:(5Z)-5-[(6-CHLORO-7-METHYL-1H-INDOL-3-YL)METHYLIDENE]-3-(3,4-DIFLUOROBENZYL)IMIDAZOLIDINE-2,4-DIONE'>03M</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03M:(5Z)-5-[(6-CHLORO-7-METHYL-1H-INDOL-3-YL)METHYLIDENE]-3-(3,4-DIFLUOROBENZYL)IMIDAZOLIDINE-2,4-DIONE'>03M</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fea|3fea]], [[3vbg|3vbg]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3fea|3fea]], [[3vbg|3vbg]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MDM4, MDMX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u15 OCA], [http://pdbe.org/3u15 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u15 RCSB], [http://www.ebi.ac.uk/pdbsum/3u15 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u15 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u15 OCA], [https://pdbe.org/3u15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u15 RCSB], [https://www.ebi.ac.uk/pdbsum/3u15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u15 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
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[[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3u15" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3u15" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[MDM4|MDM4]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Graves, B J]]
[[Category: Graves, B J]]
[[Category: Janson, C A]]
[[Category: Janson, C A]]

Revision as of 05:53, 13 July 2022

Structure of hDMX with Dimer Inducing Indolyl Hydantoin RO-2443

PDB ID 3u15

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