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2a9i

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[[Image:2a9i.gif|left|200px]]
[[Image:2a9i.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2a9i |SIZE=350|CAPTION= <scene name='initialview01'>2a9i</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2a9i", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Irak4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2a9i| PDB=2a9i | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a9i OCA], [http://www.ebi.ac.uk/pdbsum/2a9i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a9i RCSB]</span>
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}}
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'''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain'''
'''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain'''
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[[Category: Lasker, M V.]]
[[Category: Lasker, M V.]]
[[Category: Nair, S K.]]
[[Category: Nair, S K.]]
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[[Category: hexahelical bundle]]
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[[Category: Hexahelical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:46:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:49:41 2008''
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Revision as of 15:46, 3 May 2008

Image:2a9i.gif

Template:STRUCTURE 2a9i

Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain


Overview

IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.

About this Structure

2A9I is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:16177054 Page seeded by OCA on Sat May 3 18:46:53 2008

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