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5l0x
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l0x OCA], [http://pdbe.org/5l0x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l0x RCSB], [http://www.ebi.ac.uk/pdbsum/5l0x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l0x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l0x OCA], [http://pdbe.org/5l0x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l0x RCSB], [http://www.ebi.ac.uk/pdbsum/5l0x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l0x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | HapR is a TetR-family transcriptional regulator that controls quorum sensing in Vibrio cholerae, the causative agent of cholera. HapR regulates the expression of hemagglutinin protease, virulence and biofilm genes. The crystal structure of wild-type HapR from V. cholerae strain O1 El Tor C6706 has previously been solved. In this study, the structure of a DNA-binding-deficient variant of HapR (HapRV2) derived from the protease-deficient V. cholerae serotype O37 strain V2 is reported. The structure reveals no structural differences compared with wild-type HapR. However, structural alignment of HapRV2 with the TetR-family member QacR in complex with its operator DNA suggests that the aspartate residue located between the regulatory and DNA-binding domains may clash with and electrostatically repel the phosphate backbone of DNA to prevent binding. | ||
| + | |||
| + | Crystal structure of an inactive variant of the quorum-sensing master regulator HapR from the protease-deficient non-O1, non-O139 Vibrio cholerae strain V2.,Cruite J, Succo P, Raychaudhuri S, Kull FJ Acta Crystallogr F Struct Biol Commun. 2018 Jun 1;74(Pt 6):331-336. doi:, 10.1107/S2053230X18006519. Epub 2018 May 17. PMID:29870016<ref>PMID:29870016</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5l0x" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:40, 13 February 2019
Crystal structure of inactive V. cholerae quorum-sensing regulator HapR G39D
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