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5mr5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Ligand-receptor complex.== | |
| - | + | <StructureSection load='5mr5' size='340' side='right' caption='[[5mr5]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mr5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MR5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MR5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mr5 OCA], [http://pdbe.org/5mr5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mr5 RCSB], [http://www.ebi.ac.uk/pdbsum/5mr5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mr5 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Hirschsprung disease. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.<ref>PMID:9700200</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. [[http://www.uniprot.org/uniprot/GFRA2_HUMAN GFRA2_HUMAN]] Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. Isoform 2: participates in NRTN-induced 'Ser-727' phosphorylation of STAT3.[UniProtKB:O08842] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aagaard, A]] | ||
| + | [[Category: Dahl, G]] | ||
| + | [[Category: Oster, L]] | ||
| + | [[Category: Roth, R]] | ||
| + | [[Category: Sandmark, J]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Ligand-receptor complex]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Signalling]] | ||
Revision as of 06:47, 17 January 2018
Ligand-receptor complex.
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