2acf

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[[Image:2acf.gif|left|200px]]
[[Image:2acf.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2acf", creates the "Structure Box" on the page.
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02907 Macro_Af1521_BAL_like]</span>
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{{STRUCTURE_2acf| PDB=2acf | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2acf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2acf OCA], [http://www.ebi.ac.uk/pdbsum/2acf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2acf RCSB]</span>
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'''Crystal structure of ADRP domain of SARS NSP3'''
'''Crystal structure of ADRP domain of SARS NSP3'''
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[[Category: Stevens, R C.]]
[[Category: Stevens, R C.]]
[[Category: Subramanian, V.]]
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[[Category: adrp domain]]
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[[Category: Adrp domain]]
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[[Category: appr-1 -p phosphatase]]
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[[Category: Appr-1 -p phosphatase]]
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[[Category: jcsg]]
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[[Category: joint center for structural genomic]]
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[[Category: Joint center for structural genomic]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi-2]]
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[[Category: Psi-2]]
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[[Category: sars nsp-3]]
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[[Category: Sars nsp-3]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:52:26 2008''
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Revision as of 15:52, 3 May 2008

Image:2acf.gif

Template:STRUCTURE 2acf

Crystal structure of ADRP domain of SARS NSP3


Overview

The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength anomalous dispersion to 1.4 A resolution. The structure of this "X" domain, seen in many single-stranded RNA viruses, reveals a three-layered alpha/beta/alpha core with a macro-H2A-like fold. The putative active site is a solvent-exposed cleft that is conserved in its three structural homologs, yeast Ymx7, Archeoglobus fulgidus AF1521, and Er58 from E. coli. Its sequence is similar to yeast YBR022W (also known as Poa1P), a known phosphatase that acts on ADP-ribose-1-phosphate (Appr-1-p). The SARS nsP3 domain readily removes the 1 phosphate group from Appr-1-p in in vitro assays, confirming its phosphatase activity. Sequence and structure comparison of all known macro-H2A domains combined with available functional data suggests that proteins of this superfamily form an emerging group of nucleotide phosphatases that dephosphorylate Appr-1-p.

About this Structure

2ACF is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1-phosphate dephosphorylation by a conserved domain of nsP3., Saikatendu KS, Joseph JS, Subramanian V, Clayton T, Griffith M, Moy K, Velasquez J, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P, Structure. 2005 Nov;13(11):1665-75. PMID:16271890 Page seeded by OCA on Sat May 3 18:52:26 2008

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