2adc

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[[Image:2adc.gif|left|200px]]
[[Image:2adc.gif|left|200px]]
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{{Structure
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|PDB= 2adc |SIZE=350|CAPTION= <scene name='initialview01'>2adc</scene>
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The line below this paragraph, containing "STRUCTURE_2adc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= PTB-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2adc| PDB=2adc | SCENE= }}
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|RELATEDENTRY=[[2ad9|2AD9]], [[2adb|2ADB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adc OCA], [http://www.ebi.ac.uk/pdbsum/2adc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2adc RCSB]</span>
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'''Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA'''
'''Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA'''
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[[Category: Reymond, L.]]
[[Category: Reymond, L.]]
[[Category: Wenter, P.]]
[[Category: Wenter, P.]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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[[Category: rbd]]
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[[Category: Rbd]]
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[[Category: rrm]]
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[[Category: Rrm]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:54:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:51:03 2008''
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Revision as of 15:54, 3 May 2008

Image:2adc.gif

Template:STRUCTURE 2adc

Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA


Overview

The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.

About this Structure

2ADC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of PTB bound to RNA: specific binding and implications for splicing regulation., Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH, Science. 2005 Sep 23;309(5743):2054-7. PMID:16179478 Page seeded by OCA on Sat May 3 18:54:13 2008

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OCA

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