2agi

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[[Image:2agi.gif|left|200px]]
[[Image:2agi.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2agi |SIZE=350|CAPTION= <scene name='initialview01'>2agi</scene>, resolution 1.140&Aring;
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The line below this paragraph, containing "STRUCTURE_2agi", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2agi| PDB=2agi | SCENE= }}
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|RELATEDENTRY=[[2age|2AGE]], [[2agg|2AGG]], [[2ah4|2AH4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2agi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2agi OCA], [http://www.ebi.ac.uk/pdbsum/2agi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2agi RCSB]</span>
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}}
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'''The leupeptin-trypsin covalent complex at 1.14 A resolution'''
'''The leupeptin-trypsin covalent complex at 1.14 A resolution'''
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[[Category: Lu, C J.]]
[[Category: Lu, C J.]]
[[Category: Radisky, E S.]]
[[Category: Radisky, E S.]]
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[[Category: acyl-enzyme]]
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[[Category: Acyl-enzyme]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: peptidase]]
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[[Category: Peptidase]]
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[[Category: proteinase]]
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[[Category: Proteinase]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:01:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:52:20 2008''
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Revision as of 16:01, 3 May 2008

Image:2agi.gif


PDB ID 2agi

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2agi, resolution 1.14Å ()
Ligands: ,
Non-Standard Residues: ,
Activity: Trypsin, with EC number 3.4.21.4
Related: 2age, 2agg, 2ah4
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



The leupeptin-trypsin covalent complex at 1.14 A resolution


Overview

Atomic resolution structures of trypsin acyl-enzymes and a tetrahedral intermediate analog, along with previously solved structures representing the Michaelis complex, are used to reconstruct events in the catalytic cycle of this classic serine protease. Structural comparisons provide insight into active site adjustments involved in catalysis. Subtle motions of the catalytic serine and histidine residues coordinated with translation of the substrate reaction center are seen to favor the forward progress of the acylation reaction. The structures also clarify the attack trajectory of the hydrolytic water in the deacylation reaction.

About this Structure

2AGI is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates., Radisky ES, Lee JM, Lu CJ, Koshland DE Jr, Proc Natl Acad Sci U S A. 2006 May 2;103(18):6835-40. Epub 2006 Apr 24. PMID:16636277 Page seeded by OCA on Sat May 3 19:01:18 2008

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OCA

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