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4glw

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==DNA ligase A in complex with inhibitor==
==DNA ligase A in complex with inhibitor==
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<StructureSection load='4glw' size='340' side='right' caption='[[4glw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4glw' size='340' side='right'caption='[[4glw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4glw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Strzp Strzp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GLW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4glw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_P1031 Streptococcus pneumoniae P1031]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GLW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0XT:7-METHOXY-6-METHYLPTERIDINE-2,4-DIAMINE'>0XT</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0XT:7-METHOXY-6-METHYLPTERIDINE-2,4-DIAMINE'>0XT</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3baa|3baa]], [[4glx|4glx]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glw OCA], [https://pdbe.org/4glw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4glw RCSB], [https://www.ebi.ac.uk/pdbsum/4glw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4glw ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ligA, SPP_1122 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=488223 STRZP])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(NAD(+)) DNA ligase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.2 6.5.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4glw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4glw OCA], [http://pdbe.org/4glw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4glw RCSB], [http://www.ebi.ac.uk/pdbsum/4glw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4glw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNLJ_STRZP DNLJ_STRZP]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.[HAMAP-Rule:MF_01588]
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[https://www.uniprot.org/uniprot/DNLJ_STRZP DNLJ_STRZP] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.[HAMAP-Rule:MF_01588]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4glw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4glw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Strzp]]
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[[Category: Large Structures]]
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[[Category: Chambovey, A]]
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[[Category: Streptococcus pneumoniae P1031]]
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[[Category: Lange, R]]
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[[Category: Chambovey A]]
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[[Category: Prade, L]]
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[[Category: Lange R]]
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[[Category: Tidten-Luksch, N]]
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[[Category: Prade L]]
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[[Category: Dna ligase some]]
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[[Category: Tidten-Luksch N]]
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[[Category: Inhibitor]]
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[[Category: Ligase-ligase inhibitor complex]]
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Revision as of 07:04, 26 October 2022

DNA ligase A in complex with inhibitor

PDB ID 4glw

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