4i1t

<StructureSection load='4i1t' size='340' side='right' caption='[[4i1t]], [[Resolution|resolution]] 2.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[4i1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Piarv Piarv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1T FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11630 PIARV])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1t OCA], [http://pdbe.org/4i1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i1t RCSB], [http://www.ebi.ac.uk/pdbsum/4i1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1t ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/Q915A5_PIARV Q915A5_PIARV]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner (By similarity).[PIRNR:PIRNR000836]

[[Category: Piarv]]

[[Category: RNA-directed RNA polymerase]]

[[Category: Bussetta, C]]

[[Category: Choi, K H]]

[[Category: Viral transcription]]