This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4isl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1==
==Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1==
-
<StructureSection load='4isl' size='340' side='right' caption='[[4isl]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
+
<StructureSection load='4isl' size='340' side='right'caption='[[4isl]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4isl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ISL FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4isl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ISL FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4is5|4is5]], [[4isn|4isn]], [[4iso|4iso]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4isl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isl OCA], [https://pdbe.org/4isl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4isl RCSB], [https://www.ebi.ac.uk/pdbsum/4isl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isl ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HAI1, SPINT1, UNQ223/PRO256 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PRSS14, SNC19, ST14, TADG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matriptase Matriptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.109 3.4.21.109] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isl OCA], [http://pdbe.org/4isl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4isl RCSB], [http://www.ebi.ac.uk/pdbsum/4isl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4isl ProSAT]</span></td></tr>
+
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/SPIT1_HUMAN SPIT1_HUMAN]] Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
+
[https://www.uniprot.org/uniprot/SPIT1_HUMAN SPIT1_HUMAN] Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 18:
</div>
</div>
<div class="pdbe-citations 4isl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4isl" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Hepatocyte growth factor activator inhibitor|Hepatocyte growth factor activator inhibitor]]
 +
*[[Matriptase 3D structures|Matriptase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Matriptase]]
+
[[Category: Large Structures]]
-
[[Category: Huang, M D]]
+
[[Category: Huang MD]]
-
[[Category: Li, R]]
+
[[Category: Li R]]
-
[[Category: Yuan, C]]
+
[[Category: Yuan C]]
-
[[Category: Zhao, B Y]]
+
[[Category: Zhao BY]]
-
[[Category: Beta barrel]]
+
-
[[Category: Epithelium]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Serine protease inhibitor]]
+

Revision as of 21:07, 16 November 2022

Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1

PDB ID 4isl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4isl"
Personal tools