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2aib

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[[Image:2aib.gif|left|200px]]
[[Image:2aib.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2aib |SIZE=350|CAPTION= <scene name='initialview01'>2aib</scene>, resolution 1.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2aib", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ERG:ERGOSTEROL'>ERG</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CIN1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4785 Phytophthora cinnamomi])
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-->
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|DOMAIN=
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{{STRUCTURE_2aib| PDB=2aib | SCENE= }}
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|RELATEDENTRY=[[2a8f|2A8F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aib OCA], [http://www.ebi.ac.uk/pdbsum/2aib PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aib RCSB]</span>
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}}
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'''beta-cinnamomin in complex with ergosterol'''
'''beta-cinnamomin in complex with ergosterol'''
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[[Category: Sousa, N.]]
[[Category: Sousa, N.]]
[[Category: Thomaz, M.]]
[[Category: Thomaz, M.]]
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[[Category: elicitin]]
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[[Category: Elicitin]]
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[[Category: phytopathogen]]
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[[Category: Phytopathogen]]
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[[Category: phytophthora]]
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[[Category: Phytophthora]]
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[[Category: sterol carrier protein]]
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[[Category: Sterol carrier protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:05:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:53:07 2008''
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Revision as of 16:05, 3 May 2008

Image:2aib.gif

Template:STRUCTURE 2aib

beta-cinnamomin in complex with ergosterol


Overview

The crystal structure of the elicitin beta-cinnamomin (beta-CIN) was determined in complex with ergosterol at 1.1 A resolution. beta-CIN/ergosterol complex crystallized in the monoclinic space group P2(1), with unit cell parameters of a = 31.0, b = 62.8, c = 50.0 A and beta = 93.4 degrees and two molecules in the asymmetric unit. Ligand extraction with chloroform followed by crystallographic analysis yielded a 1.35 A structure of beta-CIN (P4(3)2(1)2 space group) where the characteristic elicitin fold was kept. After incubation with cholesterol, a new complex structure was obtained, showing that the protein retains, after the extraction procedure, its ability to complex sterols. The necrotic effect of beta-CIN on tobacco was also shown to remain unchanged. Theoretical docking studies of the triterpene lupeol to beta-CIN provided an explanation for the apparent inability of beta-CIN to bind this ligand, as observed experimentally.

About this Structure

2AIB is a Single protein structure of sequence from Phytophthora cinnamomi. Full crystallographic information is available from OCA.

Reference

Crystal structures of the free and sterol-bound forms of beta-cinnamomin., Rodrigues ML, Archer M, Martel P, Miranda S, Thomaz M, Enguita FJ, Baptista RP, Pinho e Melo E, Sousa N, Cravador A, Carrondo MA, Biochim Biophys Acta. 2006 Jan;1764(1):110-21. Epub 2005 Oct 6. PMID:16249127 Page seeded by OCA on Sat May 3 19:05:18 2008

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