2aig

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[[Image:2aig.jpg|left|200px]]
[[Image:2aig.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2aig |SIZE=350|CAPTION= <scene name='initialview01'>2aig</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_2aig", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLE:FUROYL-LEUCINE'>FLE</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adamalysin Adamalysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.46 3.4.24.46] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2aig| PDB=2aig | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aig OCA], [http://www.ebi.ac.uk/pdbsum/2aig PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aig RCSB]</span>
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}}
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'''ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL647'''
'''ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL647'''
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[[Category: Meyer, E F.]]
[[Category: Meyer, E F.]]
[[Category: Politi, V.]]
[[Category: Politi, V.]]
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[[Category: complex (metalloprotease/inhibitor)]]
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[[Category: Metalloendopetidase]]
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[[Category: metalloendopetidase]]
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[[Category: Snake venom]]
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[[Category: snake venom]]
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[[Category: Zinc protease]]
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[[Category: zinc protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:56:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:53:08 2008''
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Revision as of 10:56, 30 April 2008

Image:2aig.jpg

Template:STRUCTURE 2aig

ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL647


Overview

Crotalus adamanteus snake venom adamalysin II is the structural prototype of the adamalysin or ADAM family comprising proteolytic domains of snake venom metalloproteinases, multimodular mammalian reproductive tract proteins, and tumor necrosis factor alpha convertase, TACE, involved in the release of the inflammatory cytokine, TNFalpha. The structure of adamalysin II in noncovalent complex with two small-molecule right-hand side peptidomimetic inhibitors (Pol 647 and Pol 656) has been solved using X-ray diffraction data up to 2.6 and 2.8 A resolution. The inhibitors bind to the S'-side of the proteinase, inserting between two protein segments, establishing a mixed parallel-antiparallel three-stranded beta-sheet and coordinate the central zinc ion in a bidentate manner via their two C-terminal oxygen atoms. The proteinase-inhibitor complexes are described in detail and are compared with other known structures. An adamalysin-based model of the active site of TACE reveals that these small molecules would probably fit into the active site cleft of this latter metalloproteinase, providing a starting model for the rational design of TACE inhibitors.

About this Structure

2AIG is a Single protein structure of sequence from Crotalus adamanteus. Full crystallographic information is available from OCA.

Reference

Structures of adamalysin II with peptidic inhibitors. Implications for the design of tumor necrosis factor alpha convertase inhibitors., Gomis-Ruth FX, Meyer EF, Kress LF, Politi V, Protein Sci. 1998 Feb;7(2):283-92. PMID:9521103 Page seeded by OCA on Wed Apr 30 13:56:47 2008

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