4jwd

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==Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(15-28)==
==Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(15-28)==
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<StructureSection load='4jwd' size='340' side='right' caption='[[4jwd]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4jwd' size='340' side='right'caption='[[4jwd]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jwd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JWD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jwd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JWD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JWD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dkx|1dkx]], [[1dky|1dky]], [[1dkz|1dkz]], [[3dpo|3dpo]], [[3dpp|3dpp]], [[3dpq|3dpq]], [[3qnj|3qnj]], [[4e81|4e81]], [[4jwc|4jwc]], [[4jwe|4jwe]], [[4jwi|4jwi]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jwd OCA], [https://pdbe.org/4jwd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jwd RCSB], [https://www.ebi.ac.uk/pdbsum/4jwd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jwd ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaK, groP, grpF, seg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jwd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jwd OCA], [http://pdbe.org/4jwd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jwd RCSB], [http://www.ebi.ac.uk/pdbsum/4jwd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jwd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI]] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332] [[http://www.uniprot.org/uniprot/CTHL3_BOVIN CTHL3_BOVIN]] Exerts, in vitro, a potent antimicrobial activity. Probably due to an impairment of the function of the respiratory chain and of energy-dependent activities in the inner membrane of susceptible microorganisms.
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[https://www.uniprot.org/uniprot/DNAK_ECOLI DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4jwd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4jwd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Bos taurus]]
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[[Category: Straeter, N]]
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[[Category: Escherichia coli K-12]]
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[[Category: Zahn, M]]
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[[Category: Large Structures]]
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[[Category: Antimicrobial peptide]]
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[[Category: Straeter N]]
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[[Category: Chaperone]]
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[[Category: Zahn M]]
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[[Category: Chaperone-antibiotic complex]]
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[[Category: Peptide binding]]
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[[Category: Peptide binding protein]]
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Revision as of 11:28, 30 November 2022

Crystal structure of the substrate binding domain of E.coli DnaK in complex with bovine Bac7(15-28)

PDB ID 4jwd

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