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4kga

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==Crystal structure of kallikrein-related peptidase 4==
==Crystal structure of kallikrein-related peptidase 4==
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<StructureSection load='4kga' size='340' side='right' caption='[[4kga]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
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<StructureSection load='4kga' size='340' side='right'caption='[[4kga]], [[Resolution|resolution]] 2.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KGA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KGA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bdg|2bdg]], [[2bdi|2bdi]], [[2bdh|2bdh]], [[4kel|4kel]], [[4k8y|4k8y]], [[4k1e|4k1e]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kga OCA], [https://pdbe.org/4kga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kga RCSB], [https://www.ebi.ac.uk/pdbsum/4kga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kga ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KLK4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kga OCA], [http://pdbe.org/4kga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kga RCSB], [http://www.ebi.ac.uk/pdbsum/4kga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kga ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
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[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[https://omim.org/entry/204700 204700]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Involved in enamel formation.<ref>PMID:15235027</ref>
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[https://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN] Involved in enamel formation.<ref>PMID:15235027</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4kga" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4kga" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Buckle, A M]]
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[[Category: Large Structures]]
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[[Category: Harris, J M]]
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[[Category: Buckle AM]]
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[[Category: Ilyichova, O V]]
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[[Category: Harris JM]]
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[[Category: Sit, K C]]
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[[Category: Ilyichova OV]]
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[[Category: Swedberg, J E]]
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[[Category: Sit KC]]
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[[Category: Veer, S J.de]]
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[[Category: Swedberg JE]]
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[[Category: Hydrolase]]
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[[Category: De Veer SJ]]
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[[Category: Kallikrein-4]]
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[[Category: Klk4]]
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[[Category: Protease]]
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[[Category: Serine protease]]
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Revision as of 11:57, 30 November 2022

Crystal structure of kallikrein-related peptidase 4

PDB ID 4kga

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