2ajl

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[[Image:2ajl.gif|left|200px]]
[[Image:2ajl.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ajl |SIZE=350|CAPTION= <scene name='initialview01'>2ajl</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2ajl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=JNH:1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE'>JNH</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DPP4, ADCP2, CD26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2ajl| PDB=2ajl | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ajl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ajl OCA], [http://www.ebi.ac.uk/pdbsum/2ajl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ajl RCSB]</span>
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}}
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'''X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor'''
'''X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor'''
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[[Category: Qiao, L.]]
[[Category: Qiao, L.]]
[[Category: Spurlino, J C.]]
[[Category: Spurlino, J C.]]
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[[Category: aminopeptidase]]
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[[Category: Aminopeptidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: protease]]
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[[Category: Protease]]
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[[Category: serine protease]]
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[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:07:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:53:33 2008''
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Revision as of 16:07, 3 May 2008

Image:2ajl.gif

Template:STRUCTURE 2ajl

X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor


Overview

The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.

About this Structure

2AJL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors., Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ, Bioorg Med Chem Lett. 2006 Jan 1;16(1):123-8. Epub 2005 Oct 19. PMID:16236500 Page seeded by OCA on Sat May 3 19:07:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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