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4lrg

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==Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide==
==Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide==
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<StructureSection load='4lrg' size='340' side='right' caption='[[4lrg]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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<StructureSection load='4lrg' size='340' side='right'caption='[[4lrg]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lrg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lrg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XB:2-[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-[1,2]OXAZOLO[5,4-C]THIENO[2,3-E]AZEPIN-6-YL]ACETAMIDE'>1XB</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1XB:2-[(6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-[1,2]OXAZOLO[5,4-C]THIENO[2,3-E]AZEPIN-6-YL]ACETAMIDE'>1XB</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lr6|4lr6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrg OCA], [https://pdbe.org/4lrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lrg RCSB], [https://www.ebi.ac.uk/pdbsum/4lrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrg ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, BRD4_HUMAN, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lrg OCA], [http://pdbe.org/4lrg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lrg RCSB], [http://www.ebi.ac.uk/pdbsum/4lrg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lrg ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4lrg" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4lrg" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Albrecht, B]]
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[[Category: Large Structures]]
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[[Category: Audia, J]]
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[[Category: Albrecht B]]
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[[Category: Bellon, S]]
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[[Category: Audia J]]
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[[Category: Bergeron, L]]
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[[Category: Bellon S]]
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[[Category: Birudukota, S]]
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[[Category: Bergeron L]]
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[[Category: Bryant, B]]
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[[Category: Birudukota S]]
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[[Category: Cote, A]]
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[[Category: Bryant B]]
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[[Category: Gehling, V]]
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[[Category: Cote A]]
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[[Category: Harmange, J C]]
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[[Category: Gehling V]]
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[[Category: Hewitt, M]]
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[[Category: Harmange J-C]]
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[[Category: Jayaram, H]]
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[[Category: Hewitt M]]
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[[Category: Joshi, S]]
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[[Category: Jayaram H]]
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[[Category: Leblanc, Y]]
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[[Category: Joshi S]]
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[[Category: Mertz, J]]
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[[Category: Leblanc Y]]
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[[Category: Nandana, B S]]
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[[Category: Mertz J]]
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[[Category: Nasveschuk, C]]
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[[Category: Nandana BS]]
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[[Category: Pardo, E]]
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[[Category: Nasveschuk C]]
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[[Category: Poy, F]]
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[[Category: Pardo E]]
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[[Category: Ravichandran, S]]
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[[Category: Poy F]]
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[[Category: Sandy, P]]
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[[Category: Ravichandran S]]
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[[Category: Sims, R]]
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[[Category: Sandy P]]
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[[Category: Taylor, A]]
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[[Category: Sims R]]
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[[Category: Vaswani, R]]
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[[Category: Taylor A]]
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[[Category: Yellapuntala, S]]
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[[Category: Vaswani R]]
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[[Category: Bet inhibitor]]
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[[Category: Yellapuntala S]]
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[[Category: Brd4 first bromodomain]]
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[[Category: Transcription regulator-inhibitor complex]]
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Revision as of 11:22, 14 December 2022

Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide

PDB ID 4lrg

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