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4n1j

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Current revision (10:26, 28 December 2022) (edit) (undo)
 
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==Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions==
==Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions==
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<StructureSection load='4n1j' size='340' side='right' caption='[[4n1j]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4n1j' size='340' side='right'caption='[[4n1j]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n1j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N1J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n1j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N1J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1j OCA], [https://pdbe.org/4n1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n1j RCSB], [https://www.ebi.ac.uk/pdbsum/4n1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1j ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n1k|4n1k]], [[4n1l|4n1l]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NLRP14, NALP14, NOD5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n1j OCA], [http://pdbe.org/4n1j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n1j RCSB], [http://www.ebi.ac.uk/pdbsum/4n1j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n1j ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NAL14_HUMAN NAL14_HUMAN]] May be involved in inflammation and spermatogenesis.
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[https://www.uniprot.org/uniprot/NAL14_HUMAN NAL14_HUMAN] May be involved in inflammation and spermatogenesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4n1j" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4n1j" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Pyrin domain|Pyrin domain]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Brandstetter, H]]
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[[Category: Large Structures]]
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[[Category: Eibl, C]]
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[[Category: Brandstetter H]]
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[[Category: Hessenberger, M]]
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[[Category: Eibl C]]
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[[Category: Wenger, J]]
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[[Category: Hessenberger M]]
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[[Category: Death domain fold]]
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[[Category: Wenger J]]
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[[Category: Innate immunity]]
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[[Category: Nod-like receptor]]
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[[Category: Protein binding]]
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[[Category: Pyrin domain]]
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[[Category: Signaling protein]]
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[[Category: Spermatogenesis]]
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Current revision

Crystal structures of NLRP14 pyrin domain reveal a conformational switch mechanism, regulating its molecular interactions

PDB ID 4n1j

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