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| | ==MHC complexed to 11mer peptide== | | ==MHC complexed to 11mer peptide== |
| - | <StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='5f1n' size='340' side='right'caption='[[5f1n]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F1N FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F1N FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f1i|5f1i]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLA-88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [https://pdbe.org/5f1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [https://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [http://pdbe.org/5f1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [http://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/E2RN10_CANLF E2RN10_CANLF]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.[SAAS:SAAS00359208] | + | [https://www.uniprot.org/uniprot/J9UGS3_CANLF J9UGS3_CANLF] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 5f1n" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 5f1n" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] |
| | + | *[[MHC 3D structures|MHC 3D structures]] |
| | + | *[[MHC I 3D structures|MHC I 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Canlf]] | + | [[Category: Canis lupus familiaris]] |
| - | [[Category: Chai, Y]] | + | [[Category: Large Structures]] |
| - | [[Category: Gao, G F]] | + | [[Category: Chai Y]] |
| - | [[Category: Liu, J]] | + | [[Category: Gao GF]] |
| - | [[Category: Qi, J]] | + | [[Category: Liu J]] |
| - | [[Category: Immune system]] | + | [[Category: Qi J]] |
| - | [[Category: Mhc]]
| + | |
| Structural highlights
Function
J9UGS3_CANLF
Publication Abstract from PubMed
Canines represent a crucial animal model for studying human diseases and organ transplantation, as well as the evolution of domestic animals. MHCs, with a central role in cellular immunity, are commonly used in the study of dog population genetics and genome evolution. However, the molecular basis for the peptide presentation of dog MHC remains largely unknown. In this study, peptide presentation by canine MHC class I DLA-88*50801 was structurally determined, revealing diversified anchoring modes of the binding peptides. Flexible and large pockets composed of both hydrophobic and hydrophilic residues can accommodate pathogen-derived peptides with diverse anchor residues, as confirmed by thermostability measurements. Furthermore, DLA-88*50801 contains an unusual alpha2 helix with a large coil in the TCR contact region. These results further our understanding of canine T cell immunity through peptide presentation of MHC class I and shed light on the molecular basis for vaccine development for canine infectious diseases, for example, canine distemper virus.
Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I.,Xiao J, Xiang W, Chai Y, Haywood J, Qi J, Ba L, Qi P, Wang M, Liu J, Gao GF J Immunol. 2016 Sep 15;197(6):2306-15. doi: 10.4049/jimmunol.1600887. Epub 2016, Aug 10. PMID:27511732[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xiao J, Xiang W, Chai Y, Haywood J, Qi J, Ba L, Qi P, Wang M, Liu J, Gao GF. Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I. J Immunol. 2016 Sep 15;197(6):2306-15. doi: 10.4049/jimmunol.1600887. Epub 2016, Aug 10. PMID:27511732 doi:http://dx.doi.org/10.4049/jimmunol.1600887
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