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2ane

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[[Image:2ane.gif|left|200px]]
[[Image:2ane.gif|left|200px]]
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{{Structure
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|PDB= 2ane |SIZE=350|CAPTION= <scene name='initialview01'>2ane</scene>, resolution 2.03&Aring;
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The line below this paragraph, containing "STRUCTURE_2ane", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Endopeptidase_La Endopeptidase La], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.53 3.4.21.53] </span>
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|GENE= lon, capR, deg, lopA, muc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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{{STRUCTURE_2ane| PDB=2ane | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ane FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ane OCA], [http://www.ebi.ac.uk/pdbsum/2ane PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ane RCSB]</span>
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'''Crystal structure of N-terminal domain of E.Coli Lon Protease'''
'''Crystal structure of N-terminal domain of E.Coli Lon Protease'''
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[[Category: Rotanova, T V.]]
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[[Category: Wlodawer, A.]]
[[Category: Wlodawer, A.]]
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[[Category: lon protease]]
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[[Category: Lon protease]]
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[[Category: lonn119]]
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[[Category: Lonn119]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:15:05 2008''
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Revision as of 16:15, 3 May 2008

Image:2ane.gif

Template:STRUCTURE 2ane

Crystal structure of N-terminal domain of E.Coli Lon Protease


Overview

We report here the first crystal structure of the N-terminal domain of an A-type Lon protease. Lon proteases are ubiquitous, multidomain, ATP-dependent enzymes with both highly specific and non-specific protein binding, unfolding, and degrading activities. We expressed and purified a stable, monomeric 119-amino acid N-terminal subdomain of the Escherichia coli A-type Lon protease and determined its crystal structure at 2.03 A (Protein Data Bank [PDB] code 2ANE). The structure was solved in two crystal forms, yielding 14 independent views. The domain exhibits a unique fold consisting primarily of three twisted beta-sheets and a single long alpha-helix. Analysis of recent PDB depositions identified a similar fold in BPP1347 (PDB code 1ZBO), a 203-amino acid protein of unknown function from Bordetella parapertussis, crystallized as part of a structural genomics effort. BPP1347 shares sequence homology with Lon N-domains and with a family of other independently expressed proteins of unknown functions. We postulate that, as is the case in Lon proteases, this structural domain represents a general protein and polypeptide interaction domain.

About this Structure

2ANE is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the N-terminal domain of E. coli Lon protease., Li M, Rasulova F, Melnikov EE, Rotanova TV, Gustchina A, Maurizi MR, Wlodawer A, Protein Sci. 2005 Nov;14(11):2895-900. Epub 2005 Sep 30. PMID:16199667 Page seeded by OCA on Sat May 3 19:15:05 2008

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