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4oca

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==Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N==
==Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N==
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<StructureSection load='4oca' size='340' side='right' caption='[[4oca]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4oca' size='340' side='right'caption='[[4oca]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4oca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OCA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4oca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OCA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2QR:(2R,3R,4S,5S)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]tetrahydro-2H-pyran-2-yl+[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+dihydrogen+diphosphate'>2QR</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2QR:(2R,3R,4S,5S)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]tetrahydro-2H-pyr+an-2-yl+[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl+dihydrogen+diphosphate'>2QR</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">yfbE, arnB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oca OCA], [https://pdbe.org/4oca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oca RCSB], [https://www.ebi.ac.uk/pdbsum/4oca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oca ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-4-amino-4-deoxy-L-arabinose_aminotransferase UDP-4-amino-4-deoxy-L-arabinose aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.87 2.6.1.87] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oca OCA], [http://pdbe.org/4oca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oca RCSB], [http://www.ebi.ac.uk/pdbsum/4oca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oca ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/F5ZUF5_SALTU F5ZUF5_SALTU]] Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity).[HAMAP-Rule:MF_01167][SAAS:SAAS022850_004_033570]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus typhimurium loeffler 1892]]
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[[Category: Large Structures]]
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[[Category: UDP-4-amino-4-deoxy-L-arabinose aminotransferase]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Lee, M]]
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[[Category: Lee M]]
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[[Category: Sousa, M C]]
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[[Category: Sousa MC]]
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[[Category: Aminotransferase]]
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[[Category: Transferase]]
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Revision as of 07:16, 25 January 2023

Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N

PDB ID 4oca

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