2apq

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[[Image:2apq.gif|left|200px]]
[[Image:2apq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2apq |SIZE=350|CAPTION= <scene name='initialview01'>2apq</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2apq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= RNASE1, RNS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
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-->
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|DOMAIN=
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{{STRUCTURE_2apq| PDB=2apq | SCENE= }}
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|RELATEDENTRY=[[1fs3|1fs3]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2apq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2apq OCA], [http://www.ebi.ac.uk/pdbsum/2apq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2apq RCSB]</span>
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}}
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'''Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.'''
'''Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.'''
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[[Category: Sambashivan, S.]]
[[Category: Sambashivan, S.]]
[[Category: Sawaya, M R.]]
[[Category: Sawaya, M R.]]
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[[Category: an active site mutant of rnase a (h119a) with an amyloidogenic expansion in the c-terminal hinge-loop region(between residues 112 and 113).]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:19:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:55:41 2008''
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Revision as of 16:19, 3 May 2008

Image:2apq.gif

Template:STRUCTURE 2apq

Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop.


Overview

Amyloid or amyloid-like fibrils are elongated, insoluble protein aggregates, formed in vivo in association with neurodegenerative diseases or in vitro from soluble native proteins, respectively. The underlying structure of the fibrillar or 'cross-beta' state has presented long-standing, fundamental puzzles of protein structure. These include whether fibril-forming proteins have two structurally distinct stable states, native and fibrillar, and whether all or only part of the native protein refolds as it converts to the fibrillar state. Here we show that a designed amyloid-like fibril of the well-characterized enzyme RNase A contains native-like molecules capable of enzymatic activity. In addition, these functional molecular units are formed from a core RNase A domain and a swapped complementary domain. These findings are consistent with the zipper-spine model in which a cross-beta spine is decorated with three-dimensional domain-swapped functional units, retaining native-like structure.

About this Structure

2APQ is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure., Sambashivan S, Liu Y, Sawaya MR, Gingery M, Eisenberg D, Nature. 2005 Sep 8;437(7056):266-9. PMID:16148936 Page seeded by OCA on Sat May 3 19:19:28 2008

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