2aq5

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[[Image:2aq5.gif|left|200px]]
[[Image:2aq5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2aq5 |SIZE=350|CAPTION= <scene name='initialview01'>2aq5</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_2aq5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Coro1a, Coro1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2aq5| PDB=2aq5 | SCENE= }}
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|RELATEDENTRY=[[2b4e|2B4E]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aq5 OCA], [http://www.ebi.ac.uk/pdbsum/2aq5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2aq5 RCSB]</span>
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}}
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'''Crystal Structure of Murine Coronin-1'''
'''Crystal Structure of Murine Coronin-1'''
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[[Category: Wu, P.]]
[[Category: Wu, P.]]
[[Category: 7-bladed beta-propeller]]
[[Category: 7-bladed beta-propeller]]
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[[Category: wd40 repeat]]
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[[Category: Wd40 repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:20:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:55:47 2008''
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Revision as of 16:20, 3 May 2008

Image:2aq5.gif

Template:STRUCTURE 2aq5

Crystal Structure of Murine Coronin-1


Overview

Mammalian coronin-1 is preferentially expressed in hematopoietic cells and plays a poorly understood role in the dynamic reorganization of the actin cytoskeleton. Sequence analysis of coronin-1 revealed five WD40 repeats that were predicted to form a beta propeller. They are followed by a 130 residue extension and a 30 residue leucine zipper domain that is responsible for multimerization of the protein. Here, we present the crystal structure of murine coronin-1 without the leucine zipper at 1.75 A resolution. Coronin-1 forms a seven-bladed beta propeller composed of the five predicted WD40 repeats and two additional blades that lack any homology to the canonical WD40 motif. The C-terminal extension adopts an extended conformation, packs tightly against the bottom surface of the propeller, and is likely to be required for the structural stability of the propeller. Analysis of charged and conserved surface residues delineate possible binding sites for F-actin on the beta propeller.

About this Structure

2AQ5 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes., Appleton BA, Wu P, Wiesmann C, Structure. 2006 Jan;14(1):87-96. PMID:16407068 Page seeded by OCA on Sat May 3 19:20:08 2008

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