2aql
From Proteopedia
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'''Crystal Structure of the MRG15 MRG domain''' | '''Crystal Structure of the MRG15 MRG domain''' | ||
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[[Category: Bowman, B R.]] | [[Category: Bowman, B R.]] | ||
[[Category: Quiocho, F A.]] | [[Category: Quiocho, F A.]] | ||
| - | [[Category: | + | [[Category: Chromatin remodeling]] |
| - | [[Category: | + | [[Category: Core binding domain]] |
| - | [[Category: | + | [[Category: Dna binding]] |
| - | [[Category: | + | [[Category: Helix hairpin]] |
| - | [[Category: | + | [[Category: Mrg domain]] |
| - | [[Category: | + | [[Category: Recombinase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:21:04 2008'' | |
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Revision as of 16:21, 3 May 2008
Crystal Structure of the MRG15 MRG domain
Overview
The ubiquitous MRG/MORF family of proteins is involved in cell senescence, or the terminal loss of proliferative potential, a model for aging and tumor suppression at the cellular level. These proteins are defined by the approximately 20 kDa MRG domain that binds a plethora of transcriptional regulators and chromatin-remodeling factors, including the histone deacetylase transcriptional corepressor mSin3A and the novel nuclear protein PAM14, and they are also known components of the Tip60/NuA4 complex via interactions with the MRG binding protein (MRGBP). We present here the crystal structure of a prototypic MRG domain from human MRG15 whose core consists of two orthogonal helix hairpins. Despite the lack of sequence similarity, the core structure has surprisingly striking homology to a DNA-interacting domain of the tyrosine site-specific recombinases XerD, lambda integrase, and Cre. Site-directed mutagenesis studies based on the X-ray structure and bioinformatics identified key residues involved in the binding of PAM14 and MRGBP.
About this Structure
2AQL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain., Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA, Structure. 2006 Jan;14(1):151-8. PMID:16407074 Page seeded by OCA on Sat May 3 19:21:04 2008
