2arw
From Proteopedia
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[[Image:2arw.gif|left|200px]] | [[Image:2arw.gif|left|200px]] | ||
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'''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor''' | '''The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor''' | ||
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[[Category: Rose-John, S.]] | [[Category: Rose-John, S.]] | ||
[[Category: Schwantner, A.]] | [[Category: Schwantner, A.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:24:09 2008'' | |
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Revision as of 16:24, 3 May 2008
The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
Overview
The members of the interleukin-6-type family of cytokines interact with receptors that have a modular structure and are built of several immunoglobulin-like and fibronectin type III-like domains. These receptors have a characteristic cytokine receptor homology region consisting of two fibronectin type III-like domains defined by a set of four conserved cysteines and a tryptophan-serine-X-tryptophan-serine sequence motif. On target cells, interleukin-6 (IL-6) initially binds to its cognate alpha-receptor and subsequently to a homodimer of the signal transducer receptor gp130. The IL-6 receptor (IL-6R) consists of three extracellular domains. The N-terminal immunoglobulin-like domain is not involved in ligand binding, whereas the third membrane-proximal fibronectin-like domain (IL-6R-D3) accounts for more than 90% of the binding energy to IL-6. Here, we present the solution structure of the IL-6R-D3 domain solved by multidimensional heteronuclear NMR spectroscopy.
About this Structure
2ARW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor., Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grotzinger J, Biol Chem. 2006 Sep;387(9):1255-9. PMID:16972794 Page seeded by OCA on Sat May 3 19:24:09 2008
